Policymakers, educators, and leaders are reimagining the role of Historically Black Colleges and Universities (HBCUs) in a rapidly changing educational and economic landscape. As institutions with a deep legacy of advancing social and economic equity, HBCUs face both opportunities and challenges in their pursuit of sustainability, growth, and innovation. How are HBCUs adapting their business models and academic offerings to meet the demands of the 21st century? With shifting demographics, evolving workforce needs, and increasing competition for funding, what strategies are leaders deploying to ensure long-term impact? In an era marked by technological disruption and new policy priorities, how can HBCUs continue to shape the future of education and opportunity? This panel will explore the dynamic forces shaping the next chapter for HBCUs and the critical role they play in driving systemic change.