Preventable illnesses remain a leading cause of death worldwide. Yet limited resources challenge health systems to deliver and invest in preventive services, particularly in the face of acute health crises that continue to demand attention. New approaches and technologies promise to transform how health is delivered and achieve long-term sustainability. From prevention-first health approaches to novel technologies, new models for access to healthcare, to AI and digital tools—what is coming next and how are these new approaches set to revolutionize how we think about and achieve better health for people around the world?